Niacin (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and
nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) …

Acquiring the recommended daily allowance of vitamins is crucial for maintaining
homeostatic balance in humans and other animals. A deficiency in or dysregulation of …

Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide
Adenine Dinucleotide (NAD) and has long been associated with neuronal development …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …

Systemic administration of 3-nitropropionic acid (3-NPA) is commonly used to induce
Huntington's disease (HD)-like symptoms in experimental animals. Here, the potential …

Huntington's disease (HD) is a neurodegenerative disease triggered by expansion of
polyglutamine repeats in the protein huntingtin. Mutant huntingtin (mHtt) aggregates and …

Animal models are used to better understand the various mechanisms involved in the
pathogenesis of diseases and explore potential pathways that will aid in discovering …

GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzyme for tetrahydrobiopterin (BH4)
biosynthesis; the latter is an essential factor for iNOS activation that contributes neuronal …

Evidence supports boosting nicotinamide adenine dinucleotide (NAD+) to counteract
oxidative stress in aging and neurodegenerative disease. One approach is to enhance the …

Huntington disease (HD) is a neurodegenerative condition and one of the so-called rare or
minority diseases, due to its low prevalence (affecting 1–10 of every 100,000 people in …