The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …

The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …

Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …

The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …

The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of
inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer had distinct …

Macrophages contribute to the pathogenesis of rheumatoid arthritis (RA). They can display
different states of activation or “polarization,” notably the so-called inflammatory “M1” and the …

The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular
physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly …

The control of inflammation is strictly regulated to ensure the adequate intensity and duration
of an inflammatory response, enabling the removal of the trigger factors and the restoration …

Abstract The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen
host innate immune responses following engagement with their ligands Gas6 and Protein S …

The TAM receptor protein tyrosine kinases—Tyro3, Axl, and Mer—are essential regulators of
immune homeostasis. Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) …