Sarcopenic obesity in liver cirrhosis: possible mechanism and clinical impact

H Nishikawa, H Enomoto, S Nishiguchi… - International Journal of …, 2021 - mdpi.com
The picture of chronic liver diseases (CLDs) has changed considerably in recent years. One
of them is the increase of non-alcoholic fatty liver disease. More and more CLD patients …

prognostic significance of body composition abnormalities in patients with cirrhosis

M Ebadi, RA Bhanji, P Tandon… - Alimentary …, 2020 - Wiley Online Library
Background Recent advances in evaluation of body composition show body mass index to
be inadequate in differentiating between body compartments in cirrhosis. Given the …

Automated body composition analysis of clinically acquired computed tomography scans using neural networks

MT Paris, P Tandon, DK Heyland, H Furberg, T Premji… - Clinical Nutrition, 2020 - Elsevier
Background & aims The quantity and quality of skeletal muscle and adipose tissue is an
important prognostic factor for clinical outcomes across several illnesses. Clinically acquired …

Myosteatosis, but not sarcopenia, predisposes NAFLD subjects to early steatohepatitis and fibrosis progression

YC Hsieh, SK Joo, BK Koo, HC Lin, DH Lee… - Clinical …, 2023 - Elsevier
Background & Aims Sarcopenia and myosteatosis are associated with advanced
nonalcoholic fatty liver disease (NAFLD). However, muscle alterations in early stage NAFLD …

The improvement in body composition including subcutaneous and visceral fat reduces ammonia and hepatic encephalopathy after transjugular intrahepatic …

S Gioia, L Ridola, L Cristofaro, M Merli… - Liver …, 2021 - Wiley Online Library
Background Sarcopenia and myosteatosis have been associated to a poor prognosis of
cirrhosis and to a higher incidence of hepatic encephalopathy (HE). The prognostic …

[HTML][HTML] Body composition predicts mortality and decompensation in compensated cirrhosis patients: a prospective cohort study

EB Tapper, P Zhang, R Garg, T Nault, K Leary… - JHEP Reports, 2020 - Elsevier
Background & Aims Body composition, particularly sarcopenia, is associated with mortality
in patients with decompensated cirrhosis undergoing transplant evaluation. Similar data are …

Muscle alterations are independently associated with significant fibrosis in patients with nonalcoholic fatty liver disease

YC Hsieh, SK Joo, BK Koo, HC Lin, W Kim - Liver International, 2021 - Wiley Online Library
Abstract Background & Aim Anthropometric data are associated with nonalcoholic fatty liver
disease (NAFLD) development and progression. We investigated whether the quantity and …

Obesity, dietary fats, and gastrointestinal cancer risk-potential mechanisms relating to lipid metabolism and inflammation

KAJ Mitchelson, F O'Connell, J O'Sullivan, HM Roche - Metabolites, 2024 - mdpi.com
Obesity is a major driving factor in the incidence, progression, and poor treatment response
in gastrointestinal cancers. Herein, we conducted a comprehensive analysis of the impact of …

Global Leadership Initiative on Malnutrition-defined malnutrition coexisting with visceral adiposity predicted worse long-term all-cause mortality among inpatients with …

H Wang, T Zhao, G Guo, W Yang, X Zhang, F Yang… - Nutrition & …, 2024 - nature.com
Background/objectives Malnutrition coexisting with abdominal adipose tissue accumulation
bring a double burden on prognosis. More recently, the Global Leadership Initiative on …

Hepatic immune regulation and sex disparities

P Burra, A Zanetto, B Schnabl, T Reiberger… - Nature Reviews …, 2024 - nature.com
Chronic liver disease is a major cause of morbidity and mortality worldwide. Epidemiology,
clinical phenotype and response to therapies for gastrointestinal and liver diseases are …