CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond

AF Russo, DL Hay - Physiological reviews, 2023 - journals.physiology.org
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

A phase‐by‐phase review of migraine pathophysiology

DW Dodick - Headache: the journal of head and face pain, 2018 - Wiley Online Library
Migraine is a common, disabling neurological disorder characterized by multiple phases:
premonitory, aura, headache, postdrome, and interictal. Our understanding of the …

Migraine: multiple processes, complex pathophysiology

R Burstein, R Noseda, D Borsook - Journal of Neuroscience, 2015 - Soc Neuroscience
Migraine is a common, multifactorial, disabling, recurrent, hereditary neurovascular
headache disorder. It usually strikes sufferers a few times per year in childhood and then …

Migraine and its psychiatric comorbidities

MT Minen, OB De Dhaem, AK Van Diest… - Journal of Neurology …, 2016 - jnnp.bmj.com
Migraine is a highly prevalent and disabling neurological disorder associated with a wide
range of psychiatric comorbidities. In this manuscript, we provide an overview of the link …

Calcitonin gene-related peptide (CGRP): a new target for migraine

AF Russo - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

An update on migraine: current understanding and future directions

F Puledda, R Messina, PJ Goadsby - Journal of neurology, 2017 - Springer
Migraine is a common brain disorder with high disability rates which involves a series of
abnormal neuronal networks, interacting at different levels of the central and peripheral …

Hypothalamic regulation of headache and migraine

A May, R Burstein - Cephalalgia, 2019 - journals.sagepub.com
Background The clinical picture, but also neuroimaging findings, suggested the brainstem
and midbrain structures as possible driving or generating structures in migraine. Findings …

Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications

T Dresler, S Caratozzolo, K Guldolf, JI Huhn… - The journal of headache …, 2019 - Springer
Background Migraine is a highly prevalent and disabling neurological disorder which is
commonly linked with a broad range of psychiatric comorbidities, especially among subjects …

Analysis of trigger factors in episodic migraineurs using a smartphone headache diary applications

JW Park, MK Chu, JM Kim, SG Park, SJ Cho - PloS one, 2016 - journals.plos.org
Background Various stimuli can trigger migraines in susceptible individuals. We examined
migraine trigger factors by using a smartphone headache diary application. Method Episodic …

Distribution of CGRP and CGRP receptor components in the rat brain

K Warfvinge, L Edvinsson - Cephalalgia, 2019 - journals.sagepub.com
Background Calcitonin gene-related peptide and its receptor, consisting of receptor activity-
modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest …