Biomedical research and clinical practice are struggling to cope with the growing complexity
that the progress of health care involves. The most challenging diseases, those with the …

The geometrical representation of muscles in computational models of the musculoskeletal
system typically consists of a series of line segments. These muscle anatomies are based on …

Muscle forces and joint moments estimated by electromyography (EMG)-driven
musculoskeletal models are sensitive to the wrapping surface geometry defining muscle …

In silico clinical trials, defined as “The use of individualized computer simulation in the
development or regulatory evaluation of a medicinal product, medical device, or medical …

Background and objective Revealing the complexity behind subject-specific ankle joint
mechanics requires simultaneous analysis of three-dimensional bony and soft-tissue …

Purpose Patient-specific quantitative assessments of muscle mass and biomechanical
musculoskeletal simulations require segmentation of the muscles from medical images. The …

Neuromusculoskeletal simulation provides a promising platform to inform the design of
assistive devices or inform rehabilitation. For these applications, a simulation must be able …

Background The accurate estimation of a muscle's line of action is a fundamental
requirement in computational modelling. We present a novel anatomical muscle wrapping …

Relatively recently it has become apparent that providing human kind with a better
healthcare requires personalized, predictive and integrative medicine, for which the building …

Accurate muscle geometry (muscle length and moment arm) is required to estimate muscle
function when using musculoskeletal modelling. In shoulder, muscles are often modelled as …