Several vaccine candidates against GAS infection are in varying stages of preclinical and
clinical development. Although there is great hope that one of these vaccine candidates will …

This chapter describes current efforts to develop safe and effective vaccines to prevent S.
pyogenes infections. Although clinical development has been slow, there are a number of …

Abstract Group A Streptococcus (GAS) M protein is an important virulence factor and
potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although> …

Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed
immunostimulants suitable for vaccine antigens. Here, we show that intranasal …

A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the
exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and …

Delivery system design and adjuvant development are crucially important areas of research
for improving vaccines. Peptide amphiphile micelles are a class of biomaterials that have the …

Studies on a platform technology able to deliver low-cost viral capsomeres and virus-like
particles are described. The technology involves expression of the VP1 structural protein …

Infection with Streptococcus pyogenes, commonly known as group A Streptococcus (GAS),
is responsible for acute and postinfectious complications, including rheumatic fever and …

ABSTRACT Group A Streptococcus (GAS) is an important human pathogen responsible for
both superficial infections and invasive diseases. Autoimmune sequelae may occur upon …

86 SECTION 1 General Aspects of Vaccination age who were born to mothers who received
pertussis vaccination during pregnancy, 30, 31 thus lending further support to the current …