Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

Hypertension is a worldwide problem with major impacts on health including morbidity and
mortality, as well as consumption of health care resources. Nearly 50% of American adults …

Maintenance of brain function depends on a constant blood supply. Deficits in cerebral
blood flow are linked to cognitive decline, and they have detrimental effects on the outcome …

Vascular contributions to cognitive impairment are receiving heightened attention as
potentially modifiable factors for dementias of later life. These factors have now been linked …

Hypertension is a cardiovascular risk factor present in over two-thirds of people over age 60
in North America; elevated blood pressure correlates with increased risk of heart attack …

Vascular cognitive impairment and dementia (VCID) include a wide spectrum of chronic
manifestations of vascular disease related to large vessel strokes and small vessel disease …

Background: Cerebral small vessel disease (cSVD), a common risk factor for cognitive
impairment, involves unspecific arteriopathy characterized by hypertrophy and endothelial …

MMP activation plays a causal role in the elastogenesis (production) and elastolysis
(degradation) in the arterial wall (Figure; Table). Elastin fibers are effectively digested by …

The increasing prevalence of multifocal cerebral microhemorrhages (CMHs, also known as
“cerebral microbleeds”) is a significant, newly recognized problem in the aging population of …

Cardiovascular diseases, including atherothrombosis, are the leading cause of morbidity
and mortality in the United States, Europe, and the developed world. Matrix …