The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) has
revolutionized the field of regenerative medicine. However, recent studies on the genetic …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Patients with glioma whose tumors carry a mutation in isocitrate dehydrogenase 1
(IDH1R132H) are younger at diagnosis and live longer. IDH1 mutations co-occur with other …

Sirtuins, a family of protein deacetylases, promote cellular homeostasis by mediating
communication between cells and environment. The enzymatic activity of the mammalian …

Efficient gene editing is essential to fully utilize human pluripotent stem cells (hPSCs) in
regenerative medicine. Custom endonuclease-based gene targeting involves two …

Background Induced pluripotent stem (iPS) cells have the capability to undergo self-renewal
and differentiation into all somatic cell types. Since they can be produced through somatic …

The accuracy of replicating the genetic code is fundamental. DNA repair mechanisms
protect the fidelity of the genome ensuring a low error rate between generations. This …

Aging is characterized by a cumulative loss of genome integrity, which involves chromatin
reorganization, transcriptional dysregulation and the accumulation of DNA damage. Sirtuins …

Germline mutations in the BRCA genes are associated with a higher risk of carcinogenesis,
which is linked to an increased mutation rate and loss of the second unaffected BRCA allele …

Repair of DNA double strand breaks (DSBs) is influenced by the chemical complexity of the
lesion. Clustered lesions (complex DSBs) are generally considered more difficult to repair …