Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

A sedentary lifestyle has been linked to a number of metabolic disorders that have been
associated with sub-optimal mitochondrial characteristics and an increased risk of …

Mitochondrial health is critical for skeletal muscle function and is improved by exercise
training through both mitochondrial biogenesis and removal of damaged/dysfunctional …

Exercise and dietary intervention are currently available strategies to treat nonalcoholic fatty
liver disease (NAFLD), while the underlying mechanism remains controversial. Emerging …

Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during
aging, resulting in a disruption of cellular homeostasis and progressive degeneration and …

Moderately trained male subjects (mean age 25 years; range 19–33 years) completed an 8‐
week exercise training intervention consisting of continuous moderate cycling at 157±20 W …

Autophagy is a major degradative process activated in a rapid and transient manner to cope
with stress conditions. Whether autophagy is beneficial or detrimental depends upon the …

Aging is associated with a decline in autophagy and a state of low-grade inflammation which
further affects apoptosis and autophagy. Importantly, these alterations could reverse with …

Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is
responsive to acute increases in contractile activity patterns (ie exercise) which initiate the …