Molecular signaling pathways and therapeutic targets in hepatocellular carcinoma
M Dimri, A Satyanarayana - Cancers, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a complex biological process and is often diagnosed at
advanced stages with no effective treatment options. With advances in tumor biology and …
advanced stages with no effective treatment options. With advances in tumor biology and …
The role of signaling pathways in the development and treatment of hepatocellular carcinoma
S Whittaker, R Marais, AX Zhu - Oncogene, 2010 - nature.com
Hepatocellular carcinoma (HCC) is a highly prevalent, treatment-resistant malignancy with a
multifaceted molecular pathogenesis. Current evidence indicates that during …
multifaceted molecular pathogenesis. Current evidence indicates that during …
Hepatocellular carcinoma pathogenesis: from genes to environment
PA Farazi, RA DePinho - Nature Reviews Cancer, 2006 - nature.com
Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …
population. Despite its significance, there is only an elemental understanding of the …
Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …
is involved in several cancer developments, including NSCLC. The EGFR pathway …
EGFR signaling in liver diseases
K Komposch, M Sibilia - International journal of molecular sciences, 2015 - mdpi.com
The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase
that is activated by several ligands leading to the activation of diverse signaling pathways …
that is activated by several ligands leading to the activation of diverse signaling pathways …
Signaling pathways in hepatocellular carcinoma
T Garcia-Lezana, JL Lopez-Canovas… - Advances in cancer …, 2021 - Elsevier
Despite the recent introduction of new effective systemic agents, the survival of patients with
hepatocellular carcinoma (HCC) at advanced stages remains dismal. This underscores the …
hepatocellular carcinoma (HCC) at advanced stages remains dismal. This underscores the …
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
H Lanaya, A Natarajan, K Komposch, L Li… - Nature cell …, 2014 - nature.com
Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and
poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic …
poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic …
Dysregulation of growth factor signaling in human hepatocellular carcinoma
K Breuhahn, T Longerich, P Schirmacher - Oncogene, 2006 - nature.com
Dysregulation of pleiotropic growth factors, receptors and their downstream signaling
pathway components represent a central protumorigenic principle in human …
pathway components represent a central protumorigenic principle in human …
Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
Hepatocellular carcinoma (HCC) is associated with a poor prognosis due to late diagnoses
and a lack of effective treatment options. Epidermal growth factor receptor (EGFR)–targeted …
and a lack of effective treatment options. Epidermal growth factor receptor (EGFR)–targeted …
Hepatocellular carcinoma: molecular pathways and new therapeutic targets
LR Roberts, GJ Gores - Seminars in liver disease, 2005 - thieme-connect.com
Hepatocellular carcinoma is often diagnosed at an advanced stage, when it is not amenable
to curative therapies. There is no effective chemotherapy. Advances in cancer biology …
to curative therapies. There is no effective chemotherapy. Advances in cancer biology …