The neurobiology and control of anxious states
MJ Millan - Progress in neurobiology, 2003 - Elsevier
Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
Mechanisms Underlying Tolerance after Long‐Term Benzodiazepine Use: A Future for Subtype‐Selective GABAA Receptor Modulators?
CH Vinkers, B Olivier - Advances in Pharmacological and …, 2012 - Wiley Online Library
Despite decades of basic and clinical research, our understanding of how benzodiazepines
tend to lose their efficacy over time (tolerance) is at least incomplete. In appears that …
tend to lose their efficacy over time (tolerance) is at least incomplete. In appears that …
Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices
BACKGROUND: A limited number of reports have demonstrated abnormalities involving the
glutamate and gamma amino butyric acid systems in blood and platelets of subjects with …
glutamate and gamma amino butyric acid systems in blood and platelets of subjects with …
Regulation of GABAA receptor subunit expression by pharmacological agents
M Uusi-Oukari, ER Korpi - Pharmacological reviews, 2010 - ASPET
The γ-aminobutyric acid (GABA) type A receptor system, the main fast-acting inhibitory
neurotransmitter system in the brain, is the pharmacological target for many drugs used …
neurotransmitter system in the brain, is the pharmacological target for many drugs used …
GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon
Rationale Cortical γ-aminobutyric acid (GABA) ergic neurons contribute to the orchestration
of pyramidal neuron population firing as follows:(1) by releasing GABA on GABA A and …
of pyramidal neuron population firing as follows:(1) by releasing GABA on GABA A and …
Abuse and dependence liability of benzodiazepine-type drugs: GABAA receptor modulation and beyond
SC Licata, JK Rowlett - Pharmacology Biochemistry and Behavior, 2008 - Elsevier
Over the past several decades, benzodiazepines and the newer non-benzodiazepines have
become the anxiolytic/hypnotics of choice over the more readily abused barbiturates. While …
become the anxiolytic/hypnotics of choice over the more readily abused barbiturates. While …
Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse
WS Liu, C Pesold, MA Rodriguez… - Proceedings of the …, 2001 - National Acad Sciences
Heterozygous reeler mice (HRM) haploinsufficient for reelin express≈ 50% of the brain
reelin content of wild-type mice, but are phenotypically different from both wild-type mice and …
reelin content of wild-type mice, but are phenotypically different from both wild-type mice and …
Neuroadaptive processes in GABAergic and glutamatergic systems in benzodiazepine dependence
C Allison, JA Pratt - Pharmacology & therapeutics, 2003 - Elsevier
Knowledge of the neural mechanisms underlying the development of benzodiazepine (BZ)
dependence remains incomplete. The γ-aminobutyric acid (GABAA) receptor, being the …
dependence remains incomplete. The γ-aminobutyric acid (GABAA) receptor, being the …
The Vogel conflict test: procedural aspects, γ-aminobutyric acid, glutamate and monoamines
MJ Millan, M Brocco - European journal of pharmacology, 2003 - Elsevier
A multitude of mechanisms are involved in the control of emotion and in the response to
stress. These incorporate mediators/targets as diverse as γ-aminobutyric acid (GABA) …
stress. These incorporate mediators/targets as diverse as γ-aminobutyric acid (GABA) …
The decreased phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in the central amygdala acts as a molecular …
SC Pandey, A Roy, H Zhang - Alcoholism: Clinical and …, 2003 - Wiley Online Library
Background: Several lines of evidence indicate a high comorbidity between anxiety and
alcohol abuse. This study investigated the molecular mechanisms in the amygdaloid …
alcohol abuse. This study investigated the molecular mechanisms in the amygdaloid …