Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (DOA) are
the two most common inherited optic neuropathies in the general population. Both disorders …

Leber hereditary optic neuropathy (LHON) is one of the most common inherited optic
neuropathies causing bilateral central vision loss. The disorder results from point mutations …

REVERSE is a randomized, double-masked, sham-controlled, multicenter, phase 3 clinical
trial that evaluated the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects …

Purpose To evaluate the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects
with visual loss from Leber hereditary optic neuropathy (LHON). Design RESCUE is a …

Major advances in understanding the pathogenesis of inherited metabolic disease caused
by mitochondrial DNA mutations have yet to translate into treatments of proven efficacy …

Mitochondrial optic neuropathies constitute an important cause of chronic visual morbidity
and registrable blindness in both the paediatric and adult population. It is a genetically …

Abstract Treatment of mitochondrial respiratory chain (MRC) disorders is extremely difficult,
however, coenzyme Q 10 (CoQ 10) and its synthetic analogues are the only agents which …

Hereditary optic neuropathies result from defects in the human genome, both nuclear and
mitochondrial. The two main and most recognised phenotypes are dominant optic atrophy …

Bilateral visual loss secondary to inherited optic neuropathies is an important cause of
registrable blindness among children and young adults. The two prototypal disorders seen …

Idebenone (Raxone®), a short-chain benzoquinone, is the only disease-specific drug
approved to treat visual impairment in adolescents and adults with Leber's hereditary optic …