Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …

Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …

Ferroptosis is a new form of regulated cell death characterized by excessive iron
accumulation and uncontrollable lipid peroxidation. The role of ferroptosis in metabolic …

Ferroptosis is an iron-and lipid peroxidation-dependent cell death modality and emerging
evidence indicates that ferroptosis has great explanatory potential for neuronal loss and …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Neurodegenerative diseases are a diverse class of diseases attributed to chronic
progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord …

Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

Iron, through its participation in oxidation/reduction processes, is essential for the
physiological function of biological systems. In the brain, iron is involved in the development …