Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …

Chromatin is partitioned on multiple length scales into subcompartments that differ from
each other with respect to their molecular composition and biological function. It is a key …

In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

Chromatin is organized in a highly ordered yet dynamic manner in the cell nucleus, but the
principles governing this organization remain unclear. Similarly, it is unknown whether, and …

All eukaryotic cells contain four RNA polymerases originally defined by their sensitivity to
different drugs, and now by the sets of genes they transcribe. 1− 4 Polymerase I produces …

We developed a general approach that combines chromosome conformation capture
carbon copy (5C) with the Integrated Modeling Platform (IMP) to generate high-resolution …

Cellular proteins do not work in isolation. Instead, they often function as part of large
macromolecular complexes, which are transported and concentrated into specific cellular …

A model for all genomes involving one major architectural motif is presented: DNA or
chromatin loops are tethered to “factories” through the transcription machinery—a …

Genome information, which is three-dimensionally organized within cells as chromatin, is
searched and read by various proteins for diverse cell functions. Although how the protein …

Distinct clusters of RNA polymerase II are responsible for gene transcription inside
eukaryotic cell nuclei. Despite the functional implications of such subnuclear organization …