Immunoglobulin (Ig) superfamily proteins play diverse roles in vertebrates, including
regulation of cellular responses by sensing endogenous or exogenous ligands. Siglecs are …

The past decade has witnessed an explosion of knowledge on the impact of glia for the
neurobiological foundation of schizophrenia. A plethora of studies have shown structural …

The neuropathological basis of schizophrenia and related psychoses remains elusive
despite intensive scientific investigation. Symptoms of psychosis have been reported in a …

Genome‐wide association studies (GWAS) and whole‐exome sequencing (WES) generate
massive amounts of genomic variant information, and a major challenge is to identify which …

Recently discovered genome-wide rare copy number variants (CNVs) have unprecedented
levels of statistical association with many developmental neuropsychiatric disorders …

Siglecs, sialic acid (SA)-binding immunoglobulin (Ig)-like lectins, belong to a family of Ig-like
lectins. All Siglecs have at least two domains including an extracellular domain with variable …

Sialic acids, a group of acidic sugars abundantly expressed in the tissues of deuterostome
animals but rarely found in microbes, serve as a “signature of self” for these animals …

Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian
cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the …

Aims Growing evidence correlate the accrual of the sphingolipid ceramide in plasma and
cardiac tissue with heart failure (HF). Regulation of sphingolipid metabolism in the heart and …

Schizophrenia is one of the most serious psychiatric disorders and is characterized by
reductions in both brain volume and spine density in the frontal cortex. RhoA belongs to the …