Current knowledge of the biochemistry of Trypanosoma cruzi has led to the development of
new drugs and the understanding of their mode of action. Some trypanocidal drugs such as …

Lipid bodies are lipid-rich organelles found in the cytoplasm of a variety of cells, including
leukocytes. Lipid body morphology, its ability to interact with other organelles and its …

The production of nitric oxide (NO) is a key defense mechanism against intracellular
pathogens but it must be tightly controlled in order to avoid excessive detrimental oxidative …

A type 1 cytokine‐dependent proinflammatory response inducing classically activated
macrophages (CaMϕs) is crucial for parasite control during protozoan infections but can …

Objective and design The correlation between innate immune responses and formation of
cytoplasmic lipid bodies (LBs) was investigated in vivo in inflammatory macrophages from …

Three-part white blood cell differentials which are key to routine blood workups are typically
performed in centralized laboratories on conventional hematology analyzers operated by …

In Chagas disease, which is caused by Trypanosoma cruzi, macrophages and
cardiomyocytes are the main targets of infection. Classical activation of macrophages during …

Synthetic thiosemicarbazones and semicarbazones were evaluated for their Trypanosoma
cruzi trypomastigotes obtained from LLC-MK2 cell cultures. In general, thiosemicarbazone …

The flagellated protozoa Trypanosoma cruzi is the causal agent of Chagas′ disease, a
significant public health issue and still a major cause of morbidity and mortality in Latin …

The distinct ability of phagocytes to present antigens, produce cytokines and provide co-
stimulatory signals may contribute to the severity of the outcome of Chagas disease. In this …