Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …

Adenosine tonically inhibits synaptic transmission through actions at A1 receptors. It also
facilitates synaptic transmission, but it is unclear if this facilitation results from pre-and/or …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

Neurotransmitter release and the role of adenosine in its regulation has been investigated
for more than twenty years, and it is now widely accepted that adenosine tonically inhibits …

Adenosine either inhibits or facilitates synaptic transmission through A1 or A2A receptors,
respectively. Since A2A receptor density increases in the limbic cortex of aged (24 mo) …

To clarify the mechanisms of interaction between adenosine A 1 receptor (A1-R) and
adenosine A2 receptor (A2-R) on neurotransmitter release, this study determined the …

Pain represents an international burden and a major socio-economic public health problem.
New findings, detailed in this review, suggest that adenosine plays a significant role in …

The vertebrate neuromuscular junction (NMJ) is a specialised chemical synapse involved in
the transmission of bioelectric signals between a motor neuron and a skeletal muscle fiber …

The crosstalk between adenosine and muscarinic autoreceptors regulating evoked [3H]‐
acetylcholine ([3H]‐ACh) release was investigated on rat phrenic nerve‐hemidiaphragm …