Recent updates on viral Oncogenesis: Available preventive and therapeutic entities
Human viral oncogenesis is a complex phenomenon and a major contributor to the global
cancer burden. Several recent findings revealed cellular and molecular pathways that …
cancer burden. Several recent findings revealed cellular and molecular pathways that …
Anticancer potential of cardiac glycosides and steroid-azole hybrids
Y Hou, C Shang, T Meng, W Lou - Steroids, 2021 - Elsevier
Steriods are well-known scaffolds that have a widespread occurrence in different
compounds characterized by extensive biological properties including anticancer activity …
compounds characterized by extensive biological properties including anticancer activity …
Discovery of novel pyrazolo [3, 4-b] pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells
MS Nafie, AM Amer, AK Mohamed… - Bioorganic & Medicinal …, 2020 - Elsevier
Pim-1 kinase targeted recently has proved an essential goal of breast cancer therapy. We
report the design, synthesis with full characterization analysis of pyrazolo [3, 4-b] pyridine …
report the design, synthesis with full characterization analysis of pyrazolo [3, 4-b] pyridine …
Synthesis and molecular docking of some novel 3-thiazolyl-coumarins as inhibitors of VEGFR-2 kinase
One crucial strategy for the treatment of breast cancer involves focusing on the Vascular
Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the …
Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the …
Mechanochemical synthesis and molecular docking studies of new azines bearing indole as anticancer agents
MS Ibrahim, B Farag, J Y. Al-Humaidi, MEA Zaki… - Molecules, 2023 - mdpi.com
The development of new approaches for the synthesis of new bioactive heterocyclic
derivatives is of the utmost importance for pharmaceutical industry. In this regard, the …
derivatives is of the utmost importance for pharmaceutical industry. In this regard, the …
Hepatocellular Carcinoma cells: activity of Amygdalin and Sorafenib in Targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death
Abstract Background Sorafenib (Sor) is the only approved multikinase inhibitor indicated for
the treatment of HCC. Previous studies have shown that amygdalin (Amy) possesses …
the treatment of HCC. Previous studies have shown that amygdalin (Amy) possesses …
[HTML][HTML] Green synthesis and molecular docking study of some new thiazoles using terephthalohydrazide chitosan hydrogel as ecofriendly biopolymeric catalyst
Terephthalohydrazide chitosan hydrogel (TCs) was prepared and investigated as an
ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole …
ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole …
Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches
ATA Boraei, EH Eltamany, IAI Ali, SM Gebriel… - Bioorganic …, 2021 - Elsevier
Liver cancer is the most common type of cancer in many countries. New studies and
statistics show rising liver cancer worldwide, so it is essential to seek new agents for this …
statistics show rising liver cancer worldwide, so it is essential to seek new agents for this …
Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro …
A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4, 5, 6, 7-
tetrahydrobenzo [b] thiophene-3-carboxylate 1. An interesting cyclization was obtained …
tetrahydrobenzo [b] thiophene-3-carboxylate 1. An interesting cyclization was obtained …
Synthesis, DFT calculations, In silico studies, and biological evaluation of pyrano [2, 3-c] pyrazole and pyrazolo [4′, 3′: 5, 6] pyrano [2, 3‐d] pyrimidine derivatives
An eco-friendly approach was conducted for synthesizing pyrano [2, 3-c] pyrazoles M1-M25
via a one-pot reaction of hydrazine hydrate 99%, ethyl acetoacetate or diethyl malonate …
via a one-pot reaction of hydrazine hydrate 99%, ethyl acetoacetate or diethyl malonate …