Dynamics and functions of lipid droplets
JA Olzmann, P Carvalho - Nature reviews Molecular cell biology, 2019 - nature.com
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …
[HTML][HTML] Triglyceride metabolism in the liver
M Alves-Bezerra, DE Cohen - Comprehensive physiology, 2017 - ncbi.nlm.nih.gov
Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …
Lipid droplet functions beyond energy storage
Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …
for energy metabolism. Their function in energy storage is firmly established and …
The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state
L Hodson, PJ Gunn - Nature Reviews Endocrinology, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is an increasing global public health burden.
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …
Lipid droplets in health and disease
Lipids are essential building blocks synthesized by complex molecular pathways and
deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found …
deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found …
Lipid droplets and cellular lipid metabolism
TC Walther, RV Farese Jr - Annual review of biochemistry, 2012 - annualreviews.org
Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the
aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores …
aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores …
Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets
Lipid droplets (LDs) store metabolic energy and membrane lipid precursors. With excess
metabolic energy, cells synthesize triacylglycerol (TG) and form LDs that grow dramatically …
metabolic energy, cells synthesize triacylglycerol (TG) and form LDs that grow dramatically …
Seipin regulates ER–lipid droplet contacts and cargo delivery
Seipin is an endoplasmic reticulum (ER) membrane protein implicated in lipid droplet (LD)
biogenesis and mutated in severe congenital lipodystrophy (BSCL 2). Here, we show that …
biogenesis and mutated in severe congenital lipodystrophy (BSCL 2). Here, we show that …
[HTML][HTML] Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …
[HTML][HTML] Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis
I Anastasia, N Ilacqua, A Raimondi, P Lemieux… - Cell Reports, 2021 - cell.com
Contacts between organelles create microdomains that play major roles in regulating key
intracellular activities and signaling pathways, but whether they also regulate systemic …
intracellular activities and signaling pathways, but whether they also regulate systemic …