Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …

Nonalcoholic fatty liver disease (NAFLD) is an increasing global public health burden.
NAFLD is strongly associated with type 2 diabetes mellitus, obesity and cardiovascular …

Lipids are essential building blocks synthesized by complex molecular pathways and
deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found …

Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the
aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores …

Lipid droplets (LDs) store metabolic energy and membrane lipid precursors. With excess
metabolic energy, cells synthesize triacylglycerol (TG) and form LDs that grow dramatically …

Seipin is an endoplasmic reticulum (ER) membrane protein implicated in lipid droplet (LD)
biogenesis and mutated in severe congenital lipodystrophy (BSCL 2). Here, we show that …

Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …

Contacts between organelles create microdomains that play major roles in regulating key
intracellular activities and signaling pathways, but whether they also regulate systemic …