The impact of single nucleotide polymorphism in the long non-coding MEG3 gene on microRNA-182 and microRNA-29 expression levels in the development of breast …

O Shaker, G Ayeldeen, A Abdelhamid - Frontiers in genetics, 2021 - frontiersin.org
Early-stage detection of BC is a critical factor for effective treatment of the disease and can
increase the survival rate of BC patients. Long non-coding RNAs can act as miRNA decoys …

The Association of PTEN Gene Mutations with the Breast Cancer Risk: A Systematic Review and Meta-analysis

K Yari, A Hakimi, M Mohammadi… - Biochemical …, 2023 - Springer
Breast cancer (BC) is the most common malignancy in women in western countries. A
significant part of malignant cases is caused by genetic mutation. Mutations in the gene …

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic …

AM Abdallah, NG Zaki, WH Mahmoud… - Applied …, 2021 - Wiley Online Library
In the field of transition metal chemistry, the development of transition metal‐based drugs for
the treatment of diseases such as cancer or microbial infections with minimization of adverse …

Prevalence of TP53 gene Pro72Arg (rs1042522) single nucleotide polymorphism among Egyptian breast cancer patients

S Ahmed, G Safwat, MM Moneer… - Egyptian Journal of …, 2023 - Springer
Background The P53 protein has an essential role in several cellular processes, including
DNA repair, apoptosis, and cell cycle arrest. The pathophysiology of many cancer types has …

Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis

J Kempska, L Oliveira-Ferrer, A Grottke, M Qi… - Frontiers in …, 2023 - frontiersin.org
Introduction The PI3K/AKT pathway is activated in 43-70% of breast cancer (BC)-patients
and promotes the metastatic potential of BC cells by increasing cell proliferation, invasion …

Molecular spectra and frequency patterns of somatic mutations in Arab women with breast cancer

HO Al-Shamsi, I Abu-Gheida, AS Abdulsamad… - The …, 2021 - academic.oup.com
Background The role of somatic mutations in breast cancer prognosis and management
continues to be recognized. However, data on the molecular profiles of Arab women are …

Detection of activating mutations in liquid biopsy of Egyptian breast cancer patients using targeted next-generation sequencing: a pilot study

N Kassem, H Kassem, L Kassem, M Hassan - Journal of the Egyptian …, 2021 - Springer
Background Breast cancer (BC) is the 2 nd most prevalent malignancy worldwide and is the
most prevalent cancer among Egyptian women. The number of newly described cancer …

Encapsulating halofuginone hydrobromide in TPGS polymeric micelles enhances efficacy against triple-negative breast cancer cells

R Zuo, J Zhang, X Song, S Hu, X Gao… - International Journal …, 2021 - Taylor & Francis
Background Halofuginone hydrobromide (HF) is a synthetic analogue of the naturally
occurring quinazolinone alkaloid febrifugine, which has potential therapeutic effects against …

Exploring virus presence in field-collected potato leaf samples using RNA sequencing

EA Elwan, M Rabie, EEA Aleem, FA Fattouh… - Journal of Genetic …, 2023 - Elsevier
Background The quick and accurate identification of viruses is essential for plant disease
management. Next-generation sequencing (NGS) technology may allow the discovery …

Variation Analysis in Premenopausal and Postmenopausal Breast Cancer Cases

IH Erdogdu, S Orenay-Boyacioglu… - Journal of Personalized …, 2024 - mdpi.com
Menopausal status affects the prognoses and consequences of breast cancer. Therefore,
this retrospective study aimed to reveal the molecular variation profile differences in breast …