Clonal background and routes of plasmid transmission underlie antimicrobial resistance features of bloodstream Klebsiella pneumoniae

OO Ikhimiukor, NI Zac Soligno, IJ Akintayo… - Nature …, 2024 - nature.com
Bloodstream infections caused by the opportunistic pathogen Klebsiella pneumoniae are
associated with adverse health complications and high mortality rates. Antimicrobial …

Deciphering the relative importance of genetic elements in hypervirulent Klebsiella pneumoniae to guide countermeasure development

TA Russo, U Carlino-MacDonald, ZJ Drayer… - …, 2024 - thelancet.com
Background Quantitating the contribution of phenotype-responsible elements in
hypervirulent Klebsiella pneumoniae is needed. Methods Isogenic mutants of four …

Tackling the Antimicrobial Resistance “Pandemic” with Machine Learning Tools: A Summary of Available Evidence

D Rusic, M Kumric, A Seselja Perisin, D Leskur, J Bukic… - Microorganisms, 2024 - mdpi.com
Antimicrobial resistance is recognised as one of the top threats healthcare is bound to face
in the future. There have been various attempts to preserve the efficacy of existing …

Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying blaNDM-5 and blaKPC-3 from foreign fighters …

MJ Martin, TL Luo, V Kovalchuk… - Antimicrobial Agents …, 2024 - journals.asm.org
Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying
bla NDM-5, bla KPC-3, bla CTX-M-15, and rmtB1 from a patient in Ukraine and four …

Diverse polysaccharide production and biofilm formation abilities of clinical Klebsiella pneumoniae

RL Beckman IV, E Cella, T Azarian… - npj Biofilms and …, 2024 - nature.com
Klebsiella pneumoniae infections have become a growing threat for human health. The lack
of understanding of the relationship between antibiotic resistance, mucoviscosity, and …

What defines hypervirulent Klebsiella pneumoniae?

TD Stanton, KL Wyres - EBioMedicine, 2024 - thelancet.com
Klebsiella pneumoniae is a global pathogen with remarkable genetic, phenotypic and
pathogenic diversity. 1 Strains belonging to distinct groups of lineages cause …

[HTML][HTML] Detection of carbapenemase producing Acinetobacter baumannii ST19 from Georgia and Ukraine carrying blaOXA-23, blaOXA-72, and/or blaNDM-5 …

TL Luo, MJ Martin, V Kovalchuk, V Kondratiuk… - …, 2024 - eurosurveillance.org
In 2003− 2023, amid 5,436 Acinetobacter baumannii isolates collected globally through the
Multidrug-Resistant Organism Repository and Surveillance Network, 97 were ST19PAS, 34 …

High frequency of acquired virulence factors in carbapenemase-producing Klebsiella pneumoniae isolates from a large German university hospital, 2013–2021

J Sattler, CM Ernst, J Zweigner… - Antimicrobial Agents …, 2024 - journals.asm.org
Carbapenemase-producing Klebsiella pneumoniae (CP-Kp) isolates are a public health
concern as they can cause severe hospital-acquired infections that are difficult to treat. It has …

[HTML][HTML] Deep Intraclonal Analysis for the Development of Vaccines against Drug-Resistant Klebsiella pneumoniae Lineages

A Tajuelo, E Gato, J Oteo-Iglesias… - International Journal of …, 2024 - mdpi.com
Despite its medical relevance, there is no commercial vaccine that protects the population at
risk from multidrug-resistant (MDR) Klebsiella pneumoniae infections. The availability of …

Bacteraemia associated with multiple septic localizations caused by Klebsiella pneumoniae sequence type ST660

M Jauvain, M Carrer, F Palma, C Chapuzet… - European Journal of …, 2024 - Springer
We report a case of Klebsiella pneumoniae bacteraemia in an 80-year-old man in France
with no history of travel to Asia, complicated by endogenous endophthalmitis, multiple …