There has been an upsurge in the number of clinical trials involving chemically modified
oligonucleotide-based drug candidates after the FDA approval of Vitravene, Macugen, and …

Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …

RNA therapeutics refers to the use of oligonucleotides to target primarily ribonucleic acids
(RNA) for therapeutic efforts or in research studies to elucidate functions of genes …

Nucleic acid based therapeutics have an allure for medicinal chemists due to their potential
for specific control of gene expression. Persistent efforts have resulted in the FDA approval …

The cleavage of tetramer ACAγ T was carried out using two deblocking protocols:(I) the
standard 'lowhigh TfOH'treat ment of resin with solution of 'low TfOH'–TFA/mcresol/DMS …

Nucleic acids have gained significant interest in medicine for their therapeutic and
prophylactic application. However, if delivered alone, nucleic acids are susceptible to …

The dideoxynucleoside triphosphates (ddNTPs) terminate the bio-polymerization of DNA
and become essential chemical component of DNA sequencing technology which is now …

In this work the development of new organocatalytic protocols is reported. After a brief
introduction on Organocatalysis in Chapter 1, The study of a sustainable Direct …

This chapter covers selected papers published in 2013 on chemical synthesis and medicinal
application of modified nucleotides and oligonucleotides. Nucleotides are the building …

Chemokines such as CCL2 are small proteins with molecular weights between 8-10 kDa.
They promote chemotaxis and play a vital role in the recruitment of leukocytes to the site of …