There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

When 28-year-old Henry Gray first published his anatomy book in 1858, his goal was
humble; that is, to create an affordable quick reference and teaching aid for surgeons and …

The dendritic cells (DCs) of the immune system function in innate and adaptive responses
by directing activity of various effector cells rather than serving as effectors themselves. DCs …

Myeloid cells are crucial effectors of the innate immune response and important regulators of
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …

The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

Under stress conditions such as infection or inflammation the body rapidly needs to
generate new blood cells that are adapted to the challenge. Haematopoietic cytokines are …

MiR-150 is a microRNA (miRNA) specifically expressed in mature lymphocytes, but not their
progenitors. A top predicted target of miR-150 is c-Myb, a transcription factor controlling …

Infection with hepatitis B virus (HBV) results in disparate degrees of tissue injury: the virus
can either replicate without pathological consequences or trigger immune-mediated …