Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

Acupuncture, one of the most popular complementary therapies, is best known for its ability
to provide pain relief. Accumulating evidence suggests that acupuncture may also be …

Background The effectiveness, tolerability, and safety of intravenous (IV) ketamine in adults
with treatment resistant depression (TRD) receiving care in real-word settings is insufficiently …

Objectives Despite the available therapies for treatment-resistant depression (TRD), there
are a limited number that are evidence-based and effective in this hard-to-treat population …

Major depressive disorder (MDD) is associated with circadian rhythm disruption. Yet, no
circadian rhythm biomarkers have been clinically validated for assessing antidepressant …

Low numbers of hospital-based psychiatric beds create problems for people with severe
mental illness (SMI), when they face extended emergency department (ED) waits, higher …

Several previous functional magnetic resonance imaging (fMRI) studies have demonstrated
the predictive value of brain activity during emotion processing for antidepressant response …

Background Depression is a common and debilitating disease, and even residual symptoms
of depression can cause significant functional impairment. To achieve normal functioning …

Background Symptoms of major depressive disorder (MDD) are reported to change early in
treatment with repetitive transcranial magnetic stimulation (rTMS). We evaluated early …

Background Ketamine has been established as efficacious in adults living with Treatment-
resistant Depression (TRD). Toward providing a quantifiable estimate of the clinical …