Microglia at the scene of the crime: what their transcriptomics reveal about brain health

A Arutyunov, RS Klein - Current opinion in neurology, 2023 - journals.lww.com
Microglia at the scene of the crime: what their transcriptom... : Current Opinion in Neurology
Microglia at the scene of the crime: what their transcriptomics reveal about brain health …

[HTML][HTML] Navigating the Neuroimmunomodulation Frontier: Pioneering Approaches and Promising Horizons—A Comprehensive Review

A Krsek, L Ostojic, D Zivalj, L Baticic - International Journal of Molecular …, 2024 - mdpi.com
The research in neuroimmunomodulation aims to shed light on the complex relationships
that exist between the immune and neurological systems and how they affect the human …

Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice

R Chen, BN Routh, JE Straetker, CR Gibson… - Brain, Behavior, and …, 2023 - Elsevier
The circadian system is an evolutionarily adaptive system that synchronizes biological and
physiological activities within the body to the 24 h oscillations on Earth. At the molecular …

[HTML][HTML] Ovariectomy in mice primes hippocampal microglia to exacerbate behavioral sickness responses

K Sanchez, SL Wu, R Kakkar, JS Darling… - Brain, Behavior, & …, 2023 - Elsevier
Estrogens are a group of steroid hormones that promote the development and maintenance
of the female reproductive system and secondary sex characteristics. Estrogens also …

Botulinum neurotoxin A ameliorates depressive-like behavior in a reserpine-induced Parkinson's disease mouse model via suppressing hippocampal microglial …

Y Li, Q Yin, Q Li, A Huo, T Shen, J Cao, C Liu… - Acta Pharmacologica …, 2023 - nature.com
Depression is one of the common non-motor symptoms of Parkinson's disease (PD). In the
clinic, botulinum neurotoxin A (BoNT/A) has been used to treat depression. In this study, we …

Unveiling the Secrets of the Stressed Hippocampus: Exploring Proteomic Changes and Neurobiology of Posttraumatic Stress Disorder

A Nieto-Quero, MI Infantes-López… - Cells, 2023 - mdpi.com
Intense stress, especially traumatic stress, can trigger disabling responses and in some
cases even lead to the development of posttraumatic stress disorder (PTSD). PTSD is …

Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells

LW Desmond, EM Holbrook, CTO Wright… - International Journal of …, 2023 - mdpi.com
Previous studies have shown that the in vivo administration of soil-derived bacteria with anti-
inflammatory and immunoregulatory properties, such as Mycobacterium vaccae NCTC …

Immunization with a heat-killed preparation of Mycobacterium vaccae NCTC 11659 enhances auditory-cued fear extinction in a stress-dependent manner

JE Hassell, MV Baratta, IP Fallon, PH Siebler… - Brain, Behavior, and …, 2023 - Elsevier
Stress-related psychiatric disorders including anxiety disorders, mood disorders, and trauma
and stressor-related disorders, such as posttraumatic stress disorder (PTSD), affect millions …

Neuroimmunology of healthy brain aging

LK Fonken, AD Gaudet - Current opinion in neurobiology, 2022 - Elsevier
Aging involves progressive deterioration away from homeostasis. Whereas the healthy adult
brain maintains neuroimmune cells in a surveillant and homeostatic state, aged glial cells …

[PDF][PDF] 电针预处理对老龄大鼠长期术后认知功能障碍影响及相关机制

王志刚, 苑进革, 徐朋, 刘盼盼, 王晓茹, 陈永学… - 科学技术与工程, 2023 - stae.com.cn
摘要术后认知功能障碍(postoperative cognitive dysfunction, POCD) 是老年人群常见的并发症.
一种胆碱能依赖信号, α7-烟碱乙酰胆碱受体(α7-nAChR), 已被认为在各种神经系统疾病中调节 …