[HTML][HTML] New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities
Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and
migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells …
migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells …
Histone deacetylases (HDACs): evolution, specificity, role in transcriptional complexes, and pharmacological actionability
G Milazzo, D Mercatelli, G Di Muzio, L Triboli… - Genes, 2020 - mdpi.com
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …
removing acetyl groups from histones and other protein regulatory factors, with functional …
Drug resistance to targeted therapeutic strategies in non-small cell lung cancer
W Liu, Y Du, R Wen, M Yang, J Xu - Pharmacology & therapeutics, 2020 - Elsevier
Rapidly developing molecular biology techniques have been employed to identify cancer
driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors …
driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors …
The multidimensional role of the Wnt/β‐catenin signaling pathway in human malignancies
Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …
Piceatannol: A natural stilbene for the prevention and treatment of cancer
Abstract The World Health Organization (WHO) has documented that cancer is the second
foremost reason for death worldwide. Various factors are responsible for cancer, for …
foremost reason for death worldwide. Various factors are responsible for cancer, for …
Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases
Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …
recent development in treatment modalities, synthetic drugs have continued to show toxic …
Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets
In spite of billions of dollars expended on cancer research every year, the incidence rate and
the mortality rate due to this widespread disease has increased drastically over the last few …
the mortality rate due to this widespread disease has increased drastically over the last few …
Potential of zerumbone as an anti-cancer agent
Cancer is still a major risk factor to public health globally, causing approximately 9.8 million
deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer …
deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer …
Rationalizing the therapeutic potential of apigenin against cancer
Background Despite the remarkable advances made in the diagnosis and treatment of
cancer during the past couple of decades, it remains the second largest cause of mortality in …
cancer during the past couple of decades, it remains the second largest cause of mortality in …
Therapeutic emergence of rhein as a potential anticancer drug: a review of its molecular targets and anticancer properties
According to the World Health Organization (WHO), cancer is the second-highest cause of
mortality in the world, and it kills nearly 9.6 million people annually. Besides the fatality of the …
mortality in the world, and it kills nearly 9.6 million people annually. Besides the fatality of the …