CD4+ T helper (Th) cells play central roles in immunity in health and disease. While much is
known about the effector function of Th cells in combating pathogens and promoting …

Rapid progress has been made in the understanding of the molecular interactions that result
in cell adhesion. Many adhesive proteins present in extracellular matrices and in the blood …

The adhesive interactions of cells with other cells and with the extracellular matrix are crucial
to all developmental processes, but have a central role in the functions of the immune …

Publisher Summary Studies of cytotoxicity by human lymphocytes revealed not only that
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …

This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …

Contact between dendritic cells (DC) and resting T cells is essential to initiate a primary
immune response. Here, we demonstrate that ICAM-3 expressed by resting T cells is …

We report that diffuse large B cell lymphoma (DLBCL) commonly fails to express cell-surface
molecules necessary for the recognition of tumor cells by immune-effector cells. In 29% of …

Cytokine-activated human endothelial cells express vascular cell adhesion molecule-
l(VCAM-l), which binds lymphocytes. We now identify the in&grin VLA-4 as a receptor for …

Cell‐cell and cell‐substratum interactions are mediated through several different families of
receptors. In addition to targeting cell adhesion to specific extracellular matrix proteins and …

PU. 1 is a member of the ets family of transcription factors and is expressed exclusively in
cells of the hematopoietic lineage. Mice homozygous for a disruption in the PU. 1 DNA …