Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Post-stroke depression (PSD) is a biopsychosocial disorder that affects individuals who
have suffered a stroke at any point. PSD has a 20 to 60 percent reported prevalence among …

Ischemic stroke has been considered one of the leading causes of mortality and disability
worldwide, associated with a series of complex pathophysiological processes. However …

The constant failure of new neuroprotective therapies for ischemic stroke has partially halted
the search for new therapies in recent years, mainly because of the high investment risk …

Biomarkers are measurable substances that could be used as objective indicators for
disease diagnosis, responses to treatments, and outcomes predictions. In this review, we …

Based on the etiology, stroke can be classified into ischemic or hemorrhagic subtypes,
which ranks second among the leading causes of death. Stroke is caused not only by …

Regardless of the progress made in the pathogenesis of ischemic stroke, it remains a
leading cause of adult disability and death. To date, the most effective treatment for ischemic …

Obesity and Type 2 diabetes (T2D) are known to exacerbate cerebral injury caused by
stroke. Metabolomics can provide signatures of metabolic disease, and now we explored …

Following ischemic stroke astrocytes undergo rapid molecular and functional changes that
may accentuate tissue damage. In this study we identified the neurotrophin receptor TrkB in …

Ischemic stroke (IS) is a leading cause of death and disability worldwide. Currently, the main
therapeutic strategy involves the use of intravenous thrombolysis to restore cerebral blood …