From cancer to COVID‐19: A perspective on targeting heparan sulfate‐protein interactions
Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on
cell surfaces and in the extracellular matrix. HS interacts with numerous proteins to mediate …
cell surfaces and in the extracellular matrix. HS interacts with numerous proteins to mediate …
Platelet factor 4 polyanion immune complexes: heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia
Background This is a review article on heparin-induced thrombocytopenia, an adverse effect
of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in …
of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in …
Structural characteristics of heparin binding to SARS-CoV-2 spike protein RBD of Omicron sub-lineages BA. 2.12. 1, BA. 4 and BA. 5
The now prevalent Omicron variant and its subvariants/sub-lineages have led to a significant
increase in COVID-19 cases and raised serious concerns about increased risk of infectivity …
increase in COVID-19 cases and raised serious concerns about increased risk of infectivity …
Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus
Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has resulted in a
pandemic and continues to spread at an unprecedented rate around the world. Although a …
pandemic and continues to spread at an unprecedented rate around the world. Although a …
New insights into the binding of PF4 to long heparin oligosaccharides in ultralarge complexes using mass spectrometry
Background Heparin-induced thrombocytopenia (HIT) is a serious complication caused by
heparin drugs. The ultralarge complexes formed by platelet factor 4 (PF4) with heparin or …
heparin drugs. The ultralarge complexes formed by platelet factor 4 (PF4) with heparin or …
Chemobiocatalytic Synthesis of a low-molecular-weight heparin
Heparin products are widely used clinical anticoagulants essential in the practice of modern
medicine. Low-molecular-weight heparins (LMWHs) are currently prepared by the controlled …
medicine. Low-molecular-weight heparins (LMWHs) are currently prepared by the controlled …
Immune-stealth VP28-conjugated heparin nanoparticles for enhanced and reversible anticoagulation
Heparins are a family of sulfated linear negatively charged polysaccharides that have been
widely used for their anticoagulant, antithrombotic, antitumor, anti-inflammatory, and antiviral …
widely used for their anticoagulant, antithrombotic, antitumor, anti-inflammatory, and antiviral …
Interactions of marine sulfated glycans with antithrombin and platelet factor 4
The molecular interactions of sulfated glycans, such as heparin, with antithrombin (AT) and
platelet factor 4 (PF4) are essential for certain biological events such as anticoagulation and …
platelet factor 4 (PF4) are essential for certain biological events such as anticoagulation and …
Exploring the Interactions of Biologically Active Compounds (Including Drugs) with Biomolecules: Utilizing Surface Plasmon Resonance and SwitchSense Techniques
An important aspect of the search for new drugs is an approach that identifies a specific
molecular target involved in the disease process and develops an agent that interacts with …
molecular target involved in the disease process and develops an agent that interacts with …
Quality control, safety assessment and preparation approaches of low molecular weight heparin
Y Yu, Y Song, Y Zhao, N Wang, B Wei, RJ Linhardt… - Carbohydrate …, 2024 - Elsevier
Abstract Low Molecular Weight Heparins (LMWHs) are well-established for use in the
prevention and treatment of thrombotic diseases, and as a substitute for unfractionated …
prevention and treatment of thrombotic diseases, and as a substitute for unfractionated …