Do tumor mechanical stresses promote cancer immune escape?

K Onwudiwe, J Najera, S Siri, M Datta - Cells, 2022 - mdpi.com
Immune evasion—a well-established cancer hallmark—is a major barrier to immunotherapy
efficacy. While the molecular mechanisms and biological consequences underpinning …

Nanoindentation study of the viscoelastic properties of human triple negative breast cancer tissues: implications for mechanical biomarkers

T Ezenwafor, V Anye, J Madukwe, S Amin, J Obayemi… - Acta Biomaterialia, 2023 - Elsevier
This paper presents the results of a combined experimental and theoretical study of the
structure and viscoelastic properties of human non-tumorigenic mammary breast tissues and …

Mechanical and metabolic interplay in the brain metastatic microenvironment

K Onwudiwe, AA Burchett, M Datta - Frontiers in Oncology, 2022 - frontiersin.org
In this Perspective, we provide our insights and opinions about the contribution—and
potential co-regulation—of mechanics and metabolism in incurable breast cancer brain …

Sustained release of alpha‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth …

T Aina, AA Salifu, S Kizhakkepura… - … Research Part B …, 2023 - Wiley Online Library
This article presents silica nanoparticles for the sustained release of AMACR antibody‐
conjugated and free doxorubicin (DOX) for the inhibition of prostate cancer cell growth …

[HTML][HTML] Single-cell mechanical assay unveils viscoelastic similarities in normal and neoplastic brain cells

K Onwudiwe, J Najera, L Holen, AA Burchett… - Biophysical …, 2024 - cell.com
Understanding cancer cell mechanics allows for the identification of novel disease
mechanisms, diagnostic biomarkers, and targeted therapies. In this study, we utilized our …

Shear Assay Protocol for the Determination of Single-Cell Material Properties (Video)| JoVE

LJ Holen, K Onwudiwe, J Najera, M Zarodniuk… - JoVE (Journal of …, 2023 - jove.com
Irregular biomechanics are a hallmark of cancer biology subject to extensive study. The
mechanical properties of a cell are similar to those of a material. A cell's resistance to stress …

[HTML][HTML] Single-cell mechanical analysis reveals viscoelastic similarities between normal and neoplastic brain cells

K Onwudiwe, J Najera, L Holen, AA Burchett… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Understanding cancer cell mechanics allows for the identification of novel disease
mechanisms, diagnostic biomarkers, and targeted therapies. In this study, we utilized our …

[PDF][PDF] Do Tumor Mechanical Stresses Promote Cancer Immune Escape?. Cells 2022, 11, 3840

K Onwudiwe, J Najera, S Siri, M Datta - 2022 - drive.google.com
Immune evasion—a well-established cancer hallmark—is a major barrier to immunotherapy
efficacy. While the molecular mechanisms and biological consequences underpinning …