Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives

R Kumar, AK Thakur, N Banerjee, A Kumar… - Drug Delivery and …, 2023 - Springer
The present work reviews the liquid antisolvent crystallization (LASC) to prepare the
nanoparticle of pharmaceutical compounds to enhance their solubility, dissolution rate, and …

Development of long-acting injectable suspensions by continuous antisolvent crystallization: An integrated bottom-up process

S Nandi, L Padrela, L Tajber, A Collas - International Journal of …, 2023 - Elsevier
Our present work elucidated the operational feasibility of direct generation and stabilization
of long-acting injectable (LAI) suspensions of a practically insoluble drug, itraconazole (ITZ) …

Residence time distribution and micromixing efficiency of a dynamic inline rotor–stator mixer

W Dolshanskiy, A Stepanyuk, E Arian… - Chemical Engineering …, 2023 - Elsevier
An industrially available dynamic inline–mixer which operates on the rotor–stator principle
was investigated for aqueous solutions with a total volume flow rate of up to 40 L/h to gain …

[HTML][HTML] Incorporative mixing in microreactors: Influence on reactions and importance of inlet designation

S Asano, T Maki, S Inoue, S Sogo, M Furuta… - Chemical Engineering …, 2023 - Elsevier
Fast mixing is an essential feature of a microreactor. This study reveals the critical role of
microscopic fluid incorporation on fast chemical reactions in a microreactor. The vortices in a …

Numerical and experimental investigations of micromixing performance and efficiency in a pore-array intensified tube-in-tube microchannel reactor

W Li, F Xia, H Qin, M Zhang, W Li, J Zhang - Chemical Engineering Journal, 2019 - Elsevier
A new kind of pore-array intensified tube-in-tube microchannel reactor (PA-TMCR) was
constructed and studied to achieve intensive micromixing performance as well as high …

Scaling up microreactors for kilogram‐scale synthesis of piperacillin: experiments and computational fluid dynamics simulations

Y Xie, Q Chen, G Huang, Y Wang, W Hu, Z Yan… - AIChE …, 2021 - Wiley Online Library
In this study, two membrane dispersion microreactors in series are used to synthesize
piperacillin with low impurity content in kilogram scale. By combining experiments and …

Application of the engulfment model in assessing micromixing time of a micro-impinging stream reactor based on the determination of impinging zone with CFD

R Gu, K Cheng, L Wen - Chemical Engineering Journal, 2021 - Elsevier
Traditionally, study on the micromixing performance within reactors mostly relied on various
competitive probe reactions through experiments or CFD simulations. In such simulations …

CFD and experimental investigations on the micromixing performance of single countercurrent-flow microchannel reactor

K Cheng, C Liu, T Guo, L Wen - Chinese Journal of Chemical Engineering, 2019 - Elsevier
Microchannel reactors are widely used in different fields due to their intensive micromixing
and, thus, high mass-transfer efficiency. In this work, a single countercurrent-flow …

Liquid–liquid two-phase mass transfer in T-type micromixers with different junctions and cylindrical pits

FH Kakavandi, M Rahimi, O Jafari, N Azimi - Chemical Engineering and …, 2016 - Elsevier
This paper reports an experimental investigation of flow pattern and liquid–liquid two-phase
mass transfer in different T-type micromixers with novel shapes. These micromixers were …

Large-scale preparation of amorphous cefixime nanoparticles by antisolvent precipitation in a high-gravity rotating packed bed

YY Kuang, ZB Zhang, ML Xie, JX Wang… - Industrial & …, 2015 - ACS Publications
To enhance the solubility and dissolution rate, and thus potentially improve the oral
bioavailability of cefixime (CFX), amorphous CFX nanoparticles were prepared via high …