Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
PT Nelson, DW Dickson, JQ Trojanowski, CR Jack… - Brain, 2019 - academic.oup.com
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …
Brain arteriolosclerosis
Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …
[PDF][PDF] X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease
Co-pathologies play an important role in the expression of the Alzheimer's disease clinical
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
phenotype and may influence treatment efficacy. Early-onset Alzheimer's disease, defined …
Sex differences in the association of global amyloid and regional tau deposition measured by positron emission tomography in clinically normal older adults
Importance Mounting evidence suggests that sex differences exist in the pathologic
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …
Redox signaling at the crossroads of human health and disease
Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …
processes with biological activities. Redox homeostasis is a prerequisite for human health …
[HTML][HTML] Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation
L Yang, R Zhou, Y Tong, P Chen, Y Shen, S Miao… - Neurobiology of …, 2020 - Elsevier
Microglia-induced neuroinflammation plays a vital role in the etiology and progression of
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and …
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and …
Molecular pathology of neurodegenerative diseases: principles and practice
GG Kovacs - Journal of clinical pathology, 2019 - jcp.bmj.com
Neurodegenerative diseases are characterised by selective dysfunction and progressive
loss of synapses and neurons associated with pathologically altered proteins that deposit …
loss of synapses and neurons associated with pathologically altered proteins that deposit …
Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression
Studies have shown that women on the Alzheimer's disease (AD) continuum have more
pathological tau in the brain and cerebrospinal fluid (CSF), than men. Some studies have …
pathological tau in the brain and cerebrospinal fluid (CSF), than men. Some studies have …
Determining a multimodal aging clock in a cohort of Chinese women
Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …
to address the unmet needs of the global aging population. However, to successfully do so …