Background: Interferon-γ–release assays (IGRAs) are alternatives to the tuberculin skin test
(TST). A recent meta-analysis showed that IGRAs have high specificity, even among …

Tuberculosis continues to cause an unacceptably high toll of disease and death among
children worldwide, particularly in the wake of the HIV epidemic. Increased international …

Abstract Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may
develop symptoms and signs of disease (tuberculosis disease) or may have no clinical …

In 2005, CDC published guidelines for using the QuantiFERON-TB Gold test (QFT-
G)(Cellestis Limited, Carnegie, Victoria, Australia)(CDC. Guidelines for using the …

The aim of these guidelines is to describe a practical but evidence-based approach to the
diagnosis and treatment of central nervous system tuberculosis in children and adults. We …

Tuberculosis control relies on the identification and preventive treatment of individuals who
are latently infected with Mycobacterium tuberculosis. However, direct identification of latent …

Background: Until recently, the tuberculin skin test was the only test for detecting latent
tuberculosis (TB) infection, but 2 ex vivo interferon-γ release assays (IGRAs) are now …

Test accuracy of interferon-γ release assays (IGRAs) for diagnosing TB differs when using
older or precommercial tools and inconsistent diagnostic criteria. This metaanalysis critically …

The century-old tuberculin skin test (TST) was until recently the only means of diagnosing
latent tuberculosis infection (LTBI). Recent advances in mycobacterial genomics and human …

BACKGROUND: Children infected with Mycobacterium tuberculosis have significant risk of
developing tuberculosis (TB) and can therefore benefit from preventive therapy …