Nucleic acids are widely used in biomedical applications because of their programmability
and biocompatibility. The light responsive nucleic acids have attracted wide attention due to …

G-quadruplex (G4) oligonucleotide secondary structures have recently attracted significant
attention as therapeutic targets owing to their occurrence in human oncogene promoter …

Base-pair-driven toehold-mediated strand displacement (BP-TMSD) is a fundamental
concept employed for constructing DNA machines and networks with a gamut of …

Imaging of species in living organisms with high spatiotemporal resolution is essential for
understanding biological processes. While functional nucleic acids (FNAs), such as catalytic …

We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated
using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a …

The synthesis of a novel modified nucleoside phosphoramidite, Acrylamide-dT-CE
phosphoramidite, obtained in three steps from commercially available starting materials, is …

In the current field of photopharmacology, molecular photoswitches are applied whose
interactions with DNA can be triggered or controlled by light. And although several …

In the research, the modulation of gene expression with a novel G-quadruplex stabiliser was
analysed. Activation by the removal of bulky hypoxia-responsive substituent enhances G …

In this study, an accurately and digitally regulated allosteric nanoswitch based on the
conformational control of two DNA hairpins was developed. By switching between UV …

The presence of metal centers with often highly conserved coordination environments is
crucial for roughly half of all proteins, having structural, regulatory, or enzymatic function. To …