Small G proteins exist in eukaryotes from yeast to human and constitute the Ras superfamily
comprising more than 100 members. This superfamily is structurally classified into five …

In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the
expression of membrane targets such as the subunits of the epithelial Na+ channel, in …

Abstract Background KCNJ2/Kir2. 1, a member of the classical inwardly rectifying potassium
channel family, is commonly expressed in a wide range of tissues and cell types. Previous …

The activity of the RAF/MEK/ERK signaling pathway is critical for the proliferation of normal
and cancerous cells. Oncogenic mutations driving the development of lung adenocarcinoma …

Regulation of PIPK (phosphatidylinositol phosphate kinase) and PtdIns (4, 5) P 2 signalling
by small G-proteins and their effectors is key to many biological functions. Through selective …

Myoblast differentiation is essential to skeletal muscle formation and repair. The earliest
detectable event leading to human myoblast differentiation is an upregulation of Kir2. 1 …

The functioning of the human heart relies on complex electrical and communication systems
that coordinate cardiac contractions and sustain rhythmicity. One of the key players …

Regulation of ion channels by heterotrimeric guanosine triphosphatases (GTPases),
activated by heptathelical membrane receptors, has been the focus of several recent …

Aldosterone induces expression and activation of the GTP-dependent signaling switch K-
Ras. This small monomeric G protein is both necessary and sufficient for activation of the …

Background: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical
practice. The ReninAngiotensin-Aldosterone-System plays a major role for the atrial …