Hypoxia signaling in cancer: Implications for therapeutic interventions

Y Zhuang, K Liu, Q He, X Gu, C Jiang, J Wu - MedComm, 2023 - Wiley Online Library
Hypoxia is a persistent physiological feature of many different solid tumors and a key driver
of malignancy, and in recent years, it has been recognized as an important target for cancer …

Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas

S Jiang, Z Wen, SS Ahn, K Cai, D Paech… - NMR in …, 2023 - Wiley Online Library
Chemical exchange saturation transfer (CEST) imaging is an important molecular magnetic
resonance imaging technique that can image numerous low‐concentration biomolecules …

Applications of radiomics and radiogenomics in high-grade gliomas in the era of precision medicine

A Fathi Kazerooni, SJ Bagley, H Akbari, S Saxena… - Cancers, 2021 - mdpi.com
Simple Summary Radiomics and radiogenomics offer new insight into high-grade glioma
biology, as well as into glioma behavior in response to standard therapies. In this article, we …

Human IDH mutant 1p/19q co-deleted gliomas have low tumor acidity as evidenced by molecular MRI and PET: a retrospective study

J Yao, A Hagiwara, C Raymond, S Shabani… - Scientific reports, 2020 - nature.com
Abstract Co-deletion of 1p/19q is a hallmark of oligodendroglioma and predicts better
survival. However, little is understood about its metabolic characteristics. In this study, we …

CEST MRI provides amide/amine surrogate biomarkers for treatment-naïve glioma sub-typing

L Mancini, S Casagranda, G Gautier, P Peter… - European Journal of …, 2022 - Springer
Purpose Accurate glioma classification affects patient management and is challenging on
non-or low-enhancing gliomas. This study investigated the clinical value of different …

Activity of a first-in-class oral hif2-alpha inhibitor, pt2385, in patients with first recurrence of glioblastoma

R Strowd, B Ellingson, C Raymond, J Yao… - Journal of neuro …, 2023 - Springer
Introduction Hypoxia inducible factor 2-alpha (HIF2α) mediates cellular responses to
hypoxia and is over-expressed in glioblastoma (GBM). PT2385 is an oral HIF2α inhibitor …

The acidic brain—glycolytic switch in the microenvironment of malignant glioma

AM Reuss, D Groos, M Buchfelder… - International journal of …, 2021 - mdpi.com
Malignant glioma represents a fatal disease with a poor prognosis and development of
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …

[HTML][HTML] Current state of pediatric neuro-oncology imaging, challenges and future directions

A Nabavizadeh, MJ Barkovich, A Mian, V Ngo… - Neoplasia, 2023 - Elsevier
Imaging plays a central role in neuro-oncology including primary diagnosis, treatment
planning, and surveillance of tumors. The emergence of quantitative imaging and radiomics …

Diagnosis of glioblastoma by immuno-positron emission tomography

E Ruiz-López, J Calatayud-Pérez, I Castells-Yus… - Cancers, 2021 - mdpi.com
Simple Summary Neuroimaging has transformed the way brain tumors are diagnosed and
treated. Although different non-invasive modalities provide very helpful information, in some …

Alterations in cellular metabolism under different grades of glioma staging identified based on a multi-omics analysis strategy

X Yan, J Li, Y Zhang, C Liang, P Liang, T Li… - Frontiers in …, 2023 - frontiersin.org
Glioma is a type of brain tumor closely related to abnormal cell metabolism. Firstly, multiple
combinatorial sequencing studies have revealed this relationship. Genomic studies have …