Hypoxia signaling in cancer: Implications for therapeutic interventions
Y Zhuang, K Liu, Q He, X Gu, C Jiang, J Wu - MedComm, 2023 - Wiley Online Library
Hypoxia is a persistent physiological feature of many different solid tumors and a key driver
of malignancy, and in recent years, it has been recognized as an important target for cancer …
of malignancy, and in recent years, it has been recognized as an important target for cancer …
Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas
Chemical exchange saturation transfer (CEST) imaging is an important molecular magnetic
resonance imaging technique that can image numerous low‐concentration biomolecules …
resonance imaging technique that can image numerous low‐concentration biomolecules …
Applications of radiomics and radiogenomics in high-grade gliomas in the era of precision medicine
Simple Summary Radiomics and radiogenomics offer new insight into high-grade glioma
biology, as well as into glioma behavior in response to standard therapies. In this article, we …
biology, as well as into glioma behavior in response to standard therapies. In this article, we …
Human IDH mutant 1p/19q co-deleted gliomas have low tumor acidity as evidenced by molecular MRI and PET: a retrospective study
Abstract Co-deletion of 1p/19q is a hallmark of oligodendroglioma and predicts better
survival. However, little is understood about its metabolic characteristics. In this study, we …
survival. However, little is understood about its metabolic characteristics. In this study, we …
CEST MRI provides amide/amine surrogate biomarkers for treatment-naïve glioma sub-typing
L Mancini, S Casagranda, G Gautier, P Peter… - European Journal of …, 2022 - Springer
Purpose Accurate glioma classification affects patient management and is challenging on
non-or low-enhancing gliomas. This study investigated the clinical value of different …
non-or low-enhancing gliomas. This study investigated the clinical value of different …
Activity of a first-in-class oral hif2-alpha inhibitor, pt2385, in patients with first recurrence of glioblastoma
Introduction Hypoxia inducible factor 2-alpha (HIF2α) mediates cellular responses to
hypoxia and is over-expressed in glioblastoma (GBM). PT2385 is an oral HIF2α inhibitor …
hypoxia and is over-expressed in glioblastoma (GBM). PT2385 is an oral HIF2α inhibitor …
The acidic brain—glycolytic switch in the microenvironment of malignant glioma
AM Reuss, D Groos, M Buchfelder… - International journal of …, 2021 - mdpi.com
Malignant glioma represents a fatal disease with a poor prognosis and development of
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …
resistance mechanisms against conventional therapeutic approaches. The distinct tumor …
[HTML][HTML] Current state of pediatric neuro-oncology imaging, challenges and future directions
A Nabavizadeh, MJ Barkovich, A Mian, V Ngo… - Neoplasia, 2023 - Elsevier
Imaging plays a central role in neuro-oncology including primary diagnosis, treatment
planning, and surveillance of tumors. The emergence of quantitative imaging and radiomics …
planning, and surveillance of tumors. The emergence of quantitative imaging and radiomics …
Diagnosis of glioblastoma by immuno-positron emission tomography
E Ruiz-López, J Calatayud-Pérez, I Castells-Yus… - Cancers, 2021 - mdpi.com
Simple Summary Neuroimaging has transformed the way brain tumors are diagnosed and
treated. Although different non-invasive modalities provide very helpful information, in some …
treated. Although different non-invasive modalities provide very helpful information, in some …
Alterations in cellular metabolism under different grades of glioma staging identified based on a multi-omics analysis strategy
X Yan, J Li, Y Zhang, C Liang, P Liang, T Li… - Frontiers in …, 2023 - frontiersin.org
Glioma is a type of brain tumor closely related to abnormal cell metabolism. Firstly, multiple
combinatorial sequencing studies have revealed this relationship. Genomic studies have …
combinatorial sequencing studies have revealed this relationship. Genomic studies have …