Regulatory mechanisms of cytoneme-based morphogen transport
During development and tissue homeostasis, cells must communicate with their neighbors
to ensure coordinated responses to instructional cues. Cues such as morphogens and …
to ensure coordinated responses to instructional cues. Cues such as morphogens and …
Actin-based protrusions at a glance
S Belian, O Korenkova, C Zurzolo - Journal of Cell Science, 2023 - journals.biologists.com
Actin-based protrusions are at the base of many fundamental cellular processes, such as
cell adhesion, migration and intercellular communication. In recent decades, the discovery …
cell adhesion, migration and intercellular communication. In recent decades, the discovery …
[HTML][HTML] Cytoneme signaling provides essential contributions to mammalian tissue patterning
During development, morphogens pattern tissues by instructing cell fate across long
distances. Directly visualizing morphogen transport in situ has been inaccessible, so the …
distances. Directly visualizing morphogen transport in situ has been inaccessible, so the …
Immersion fixation and staining of multicubic millimeter volumes for electron microscopy–based connectomics of human brain biopsies
Connectomics allows mapping of cells and their circuits at the nanometer scale in volumes
of approximately 1 mm 3. Given that the human cerebral cortex can be 3 mm in thickness …
of approximately 1 mm 3. Given that the human cerebral cortex can be 3 mm in thickness …
Direct cell-cell communication via membrane pores, gap junction channels, and tunneling nanotubes: medical relevance of mitochondrial exchange
The history of direct cell-cell communication has evolved in several small steps. First
discovered in the 1930s in invertebrate nervous systems, it was thought at first to be an …
discovered in the 1930s in invertebrate nervous systems, it was thought at first to be an …
Invaginating structures in synapses–Perspective
RS Petralia, PJ Yao, D Kapogiannis… - Frontiers in synaptic …, 2021 - frontiersin.org
Invaginating structures are common in the synapses of most animals. However, the details of
these invaginating structures remain understudied in part because they are not well …
these invaginating structures remain understudied in part because they are not well …
Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche
Asymmetric signaling and organization in the stem-cell niche determine stem-cell fates.
Here, we investigate the basis of asymmetric signaling and stem-cell organization using the …
Here, we investigate the basis of asymmetric signaling and stem-cell organization using the …
Regulated delivery controls Drosophila Hedgehog, Wingless, and Decapentaplegic signaling
R Hatori, BM Wood, G Oliveira Barbosa, TB Kornberg - Elife, 2021 - elifesciences.org
Morphogen signaling proteins disperse across tissues to activate signal transduction in
target cells. We investigated dispersion of Hedgehog (Hh), Wnt homolog Wingless (Wg), and …
target cells. We investigated dispersion of Hedgehog (Hh), Wnt homolog Wingless (Wg), and …
Curbing Rhes Actions: Mechanism-based Molecular Target for Huntington's Disease and Tauopathies
S Subramaniam, S Boregowda - CNS & Neurological Disorders …, 2024 - benthamdirect.com
A highly interconnected network of diverse brain regions is necessary for the precise
execution of human behaviors, including cognitive, psychiatric, and motor functions …
execution of human behaviors, including cognitive, psychiatric, and motor functions …
Striatal Induction and Spread of the Huntington's Disease Protein: A Novel Rhes Route
S Subramaniam - Journal of Huntington's Disease, 2022 - content.iospress.com
The CAG/CAA expansion encoding polyQ huntingtin (mutant huntingtin [mHTT]) causes
Huntington's disease (HD), which is characterized by atrophy and loss of striatal medium …
Huntington's disease (HD), which is characterized by atrophy and loss of striatal medium …