Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Severe COVID-19 is characterized by a “cytokine storm”, the mechanism of which is not yet
understood. I propose that cytokine storms result from synergistic interactions among Toll …

Objective. To explore the mechanisms of TLR9 from macrophages on mitochondrial
apoptosis in cardiomyocytes at early stage of sepsis. Methods. The in vivo and in vitro sepsis …

Treatments that target single mediators of sepsis have failed to reduce its high mortality rate.
Here we developed multifunctional tannic acid-Zn 2+-gentamicin nanoparticles (TA-Zn-Gen …

Innate lymphoid cells (ILCs) and macrophages are tissue-resident cells that play important
roles in tissue-immune homeostasis and immune regulation. ILCs are mainly distributed on …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Studies have indicated that immune dysfunction plays a central role in …

Dendritic cells (DCs) play a critical role in the immune system which sense pathogens and
present their antigens to prime the adaptive immune responses. As the progression of …

Актуальность темы исследования. В настоящее время сепсис остается ведущей
причиной летальности у пациентов в ОРИТ [133]. Его наиболее тяжелой формой …