Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
m6A RNA methylation: from mechanisms to therapeutic potential
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …
METTL3 regulates heterochromatin in mouse embryonic stem cells
Abstract METTL3 (methyltransferase-like 3) mediates the N 6-methyladenosine (m6A)
methylation of mRNA, which affects the stability of mRNA and its translation into protein …
methylation of mRNA, which affects the stability of mRNA and its translation into protein …
The interplay between m6A RNA methylation and noncoding RNA in cancer
S Ma, C Chen, X Ji, J Liu, Q Zhou, G Wang… - Journal of hematology & …, 2019 - Springer
Abstract N6-methyladenosine (m6A) methylation, one of the most common RNA
modifications, has been reported to execute important functions that affect normal life …
modifications, has been reported to execute important functions that affect normal life …
Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
Abstract N 6-methyladenosine (m6A) is a chemical modification present in multiple RNA
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …
Role of m6A RNA methylation in cardiovascular disease
Y Qin, L Li, E Luo, J Hou, G Yan… - International …, 2020 - spandidos-publications.com
Abstract N6‑methyladenosine (m6A) is the most prevalent and abundant type of internal post‑
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …
Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases
Summary N 6-methyladenosine (m 6 A) is a prevalent, reversible chemical modification of
functional RNAs and is important for central events in biology. The core m 6 A writers are …
functional RNAs and is important for central events in biology. The core m 6 A writers are …
N6-methyladenosine marks primary microRNAs for processing
The first step in the biogenesis of microRNAs is the processing of primary microRNAs (pri-
miRNAs) by the microprocessor complex, composed of the RNA-binding protein DGCR8 …
miRNAs) by the microprocessor complex, composed of the RNA-binding protein DGCR8 …
Messenger RNA modifications: form, distribution, and function
RNA contains more than 100 distinct modifications that promote the functions of stable
noncoding RNAs in translation and splicing. Recent technical advances have revealed …
noncoding RNAs in translation and splicing. Recent technical advances have revealed …
Structural insights into the molecular mechanism of the m6A writer complex
P Śledź, M Jinek - elife, 2016 - elifesciences.org
Methylation of adenosines at the N6 position (m6A) is a dynamic and abundant
epitranscriptomic mark that regulates critical aspects of eukaryotic RNA metabolism in …
epitranscriptomic mark that regulates critical aspects of eukaryotic RNA metabolism in …