Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

Neural circuits controlling breathing in mammals are organized within serially arrayed and
functionally interacting brainstem compartments extending from the pons to the lower …

The mammalian spinal cord contains a locomotor central pattern generator (CPG) that can
produce alternating rhythmic activity of flexor and extensor motoneurones in the absence of …

Mammalian central pattern generators (CPGs) producing rhythmic movements exhibit
extremely robust and flexible behavior. Network architectures that enable these features are …

The organization of neural circuits that form the locomotor central pattern generator (CPG)
and provide flexor–extensor and left–right coordination of neuronal activity remains largely …

A computational model of the mammalian spinal cord circuitry incorporating a two‐level
central pattern generator (CPG) with separate half‐centre rhythm generator (RG) and pattern …

Brainstem serotonin (5-HT) neurons modulate activity of many neural circuits in the
mammalian brain, but in many cases endogenous mechanisms have not been resolved …

Communication between neurons rests on their capacity to change their firing pattern to
encode different messages. For several vital functions, such as respiration and mastication …

Throughout the nervous system, ion gradients drive fundamental processes. Yet, the roles of
interstitial ions in brain functioning is largely forgotten. Emerging literature is now revitalizing …

A central problem in analyzing neural circuit function is establishing how intrinsic neuronal
conductances contribute to the generation of network activity. We used real-time calcium …