Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …

Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …

Networks are powerful tools to uncover functional roles of genes in phenotypic variation at a
system-wide scale. Here, we constructed a maize network map that contains the genomic …

Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons
and mitochondrial DNA–linked disease mutations, yet how these stimuli mechanistically …

Muscle contraction depends on release of Ca2+ from the sarcoplasmic reticulum (SR) and
reuptake by the Ca2+ adenosine triphosphatase SERCA. We discovered a putative muscle …

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Proteogenomics is an area of research at the interface of proteomics and genomics. In this
approach, customized protein sequence databases generated using genomic and …

Mitochondria are known to be functional organelles, but their role as a signaling unit is
increasingly being appreciated. The identification of a short open reading frame (sORF) in …

Small open reading frames (smORFs) of 100 codons or fewer are usually—if arbitrarily—
excluded from proteome annotations. Despite this, the genomes of many metazoans …

Short open reading frames (sORFs) are a common feature of all genomes, but their coding
potential has mostly been disregarded, partly because of the difficulty in determining …