With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in
Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its …

In Parkinson's disease and other synucleinopathies, the elevation of α-synuclein
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …

Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …

Phosphorylation of α-synuclein at the serine-129 site (α-syn Ser129P) is an established
pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only …

The synuclein family includes three neuronal proteins, named αsynuclein, βsynuclein, and
γsynuclein, that have peculiar structural features. αsynuclein is largely known for being a …

Abstract Alpha-synuclein (α-syn) has been suggested to have many functions including,
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …

Parkinson's disease (PD) is the second most common neurodegenerative disorder
worldwide, mainly affecting the elderly. The disease progresses gradually, with core motor …

A constant metabolism and energy supply are crucial to all organs, particularly the brain.
Age-dependent neurodegenerative diseases, such as Parkinson's disease (PD), are …