As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

The maintenance of a healthy and functional mitochondrial network is critical during
development as well as throughout life in the response to physiological adaptations and …

Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

Mitochondria produce energy in the form of ATP via oxidative phosphorylation. As defects in
oxidative phosphorylation can generate harmful reactive oxygen species, it is important that …

Mitochondrial function declines during ageing owing to the accumulation of deleterious
mitochondrial genomes and damage resulting from the localized generation of reactive …

Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial
function and to adapt cellular metabolism to stress. Using a multiomics approach in …

The mitochondrial network is not only required for the production of energy, essential
cofactors and amino acids, but also serves as a signaling hub for innate immune and …