Molecular mechanisms and treatment strategies for methamphetamine‑induced neurodegeneration, inflammation and neurotoxicity
Methamphetamine (METH) is a highly addictive psychostimulant known for its profound
impact on the nervous system. Chronic METH use leads to neurotoxicity characterized by …
impact on the nervous system. Chronic METH use leads to neurotoxicity characterized by …
The common denominators of Parkinson's disease pathogenesis and methamphetamine abuse
B Vincent, M Shukla - Current Neuropharmacology, 2024 - benthamdirect.com
The pervasiveness and mortality associated with methamphetamine abuse have doubled
during the past decade, suggesting a possible worldwide substance use crisis. Epitomizing …
during the past decade, suggesting a possible worldwide substance use crisis. Epitomizing …
The gut microbiota as a potential biomarker for methamphetamine use disorder: evidence from two independent datasets
Background Methamphetamine use disorder (MUD) poses a considerable public health
threat, and its identification remains challenging due to the subjective nature of the current …
threat, and its identification remains challenging due to the subjective nature of the current …
Immunotherapies for the treatment of drug addiction
Substance use disorders (SUD) are a serious public health concern globally. Existing
treatment platforms suffer from a lack of effectiveness. The development of immunotherapies …
treatment platforms suffer from a lack of effectiveness. The development of immunotherapies …
Tryptophan and substance abuse: mechanisms and impact
Addiction, the continuous misuse of addictive material, causes long-term dysfunction in the
neurological system. It substantially affects the control strength of reward, memory, and …
neurological system. It substantially affects the control strength of reward, memory, and …
Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheres
S Wang, L Wang, Q Bu, Q Wei, L Jiang, Y Dai… - Frontiers in …, 2023 - frontiersin.org
Introduction: Methamphetamine (METH) abuse by pregnant drug addicts causes toxic effects
on fetal neurodevelopment; however, the mechanism underlying such effect of METH is …
on fetal neurodevelopment; however, the mechanism underlying such effect of METH is …
Immunotherapeutic treatment of inflammation in mice exposed to methamphetamine
JM Loftis, S Ramani, EJ Firsick, R Hudson… - Frontiers in …, 2023 - frontiersin.org
Introduction Currently, there are no FDA-approved medications to treat methamphetamine
addiction, including the inflammatory, neurotoxic, and adverse neuropsychiatric effects. We …
addiction, including the inflammatory, neurotoxic, and adverse neuropsychiatric effects. We …
[HTML][HTML] A methamphetamine vaccine using short monoamine and diamine peptide linkers and poly-mannose
Methamphetamine (METH) substance use disorder is a long-standing and ever-growing
public health concern. Efforts to develop successful immunotherapies are ongoing with …
public health concern. Efforts to develop successful immunotherapies are ongoing with …
Vaccines to Treat Substance Use Disorders: Current Status and Future Directions
T Lu, X Li, W Zheng, C Kuang, B Wu, X Liu, Y Xue… - Pharmaceutics, 2024 - mdpi.com
Addiction, particularly in relation to psychostimulants and opioids, persists as a global health
crisis with profound social and economic ramifications. Traditional interventions, including …
crisis with profound social and economic ramifications. Traditional interventions, including …
Inhibition of GSDMD-dependent pyroptosis decreased methamphetamine self-administration in rats
Y Shen, X Gong, L Qian, Y Ruan, S Lin, Z Yu… - Brain, Behavior, and …, 2024 - Elsevier
It is widely believed that the activation of the central dopamine (DA) system is crucial to the
rewarding effects of methamphetamine (METH) and to the behavioral outcomes of METH …
rewarding effects of methamphetamine (METH) and to the behavioral outcomes of METH …