Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

The discovery of penicillin by Sir Alexander Fleming in 1928 provided us with access to a
new class of compounds useful at fighting bacterial infections: antibiotics. Ever since, a …

A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites
reported in the scientific literature up through early 2013 is presented. This comprehensive …

The struggle between humans and pathogens has taken and is continuing to take countless
lives every year. As the misusage of conventional antibiotics increases, the complexity …

Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or
“orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases …

With the rise of multi-drug resistant pathogens and the decline in number of potential new
antibiotics in development there is a fervent need to reinvigorate the natural products …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are
two types, I and II, classified according to whether they make transient single-or double …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Covering: 2008 up to 2019 The forces of biochemical adaptive evolution operate at the level
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …