Anti-PD-1 and anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations

JA Seidel, A Otsuka, K Kabashima - Frontiers in oncology, 2018 - frontiersin.org
Melanoma, a skin cancer associated with high mortality rates, is highly radio-and
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …

Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis

S Baxi, A Yang, RL Gennarelli, N Khan, Z Wang… - Bmj, 2018 - bmj.com
Objective To evaluate rates of serious organ specific immune-related adverse events,
general adverse events related to immune activation, and adverse events consistent with …

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC)

EEW Cohen, RB Bell, CB Bifulco, B Burtness… - … for immunotherapy of …, 2019 - Springer
Head and neck cancers, including those of the lip and oral cavity, nasal cavity, paranasal
sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000 new cases and …

[HTML][HTML] Current status and future directions of cancer immunotherapy

H Zhang, J Chen - Journal of cancer, 2018 - ncbi.nlm.nih.gov
In the past decades, our knowledge about the relationship between cancer and the immune
system has increased considerably. Recent years' success of cancer immunotherapy …

The society for immunotherapy of cancer consensus statement on immunotherapy for the treatment of advanced renal cell carcinoma (RCC)

BI Rini, D Battle, RA Figlin, DJ George… - … for immunotherapy of …, 2019 - Springer
The approval of immunotherapeutic agents and immunotherapy-based combination
strategies in recent years has revolutionized the treatment of patients with advanced renal …

Renal adverse effects of immune checkpoints inhibitors in clinical practice: ImmuNoTox study

M Espi, C Teuma, E Novel-Catin, D Maillet… - European Journal of …, 2021 - Elsevier
Abstract Background/objectives Acute Kidney Injury (AKI), induced by Checkpoint Inhibitors
therapies (CPI-induced AKI), is an uncommon but severe Immune-Related Adverse Event …

Immune-related ocular toxicities in solid tumor patients treated with immune checkpoint inhibitors: a systematic review

O Abdel-Rahman, H Oweira, U Petrausch… - Expert review of …, 2017 - Taylor & Francis
Introduction: Immune-related ocular toxicities are uncommon but serious adverse events that
may be associated with the use of immune checkpoint inhibitors. The objective of this review …

[HTML][HTML] Toxicity management of immunotherapy for patients with metastatic melanoma

H Linardou, H Gogas - Annals of translational medicine, 2016 - ncbi.nlm.nih.gov
Checkpoint inhibitors have revolutionized the treatment of patients with metastatic
melanoma offering improved responses and significant survival benefit. These agents are …

Immune checkpoint inhibitors associated cardiovascular immune-related adverse events

W Jo, T Won, A Daoud, D Čiháková - Frontiers in immunology, 2024 - frontiersin.org
Immune checkpoint inhibitors (ICIs) are specialized monoclonal antibodies (mAbs) that
target immune checkpoints and their ligands, counteracting cancer cell-induced T-cell …

Treatment-and immune-related adverse events of immune checkpoint inhibitors in advanced lung cancer

J Shao, C Wang, P Ren, Y Jiang, P Tian… - Bioscience …, 2020 - portlandpress.com
Abstract Background: Immune checkpoint inhibitors (ICIs) emerged as the preferred therapy
in advanced lung cancer, understanding the treatment-and immune-related adverse events …