Emodin up‐regulates glucose metabolism, decreases lipolysis, and attenuates inflammation in vitro 大黄素在体内上调糖代谢, 减少脂解和抑制炎症反应
X Zhang, R Zhang, P Lv, J Yang, Y Deng… - Journal of …, 2015 - Wiley Online Library
摘要背景: 大黄素是掌叶大黄的主要生物活性成分, 具有多种的功效, 包括抗肿瘤,
抗炎以及预防糖尿病等作用. 最近有报道大黄素具有调节能量代谢的作用. 在本研究中 …
抗炎以及预防糖尿病等作用. 最近有报道大黄素具有调节能量代谢的作用. 在本研究中 …
CHIP−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications
SM Kim, JP Grenert, C Patterson, MA Correia - Scientific reports, 2016 - nature.com
Genetic ablation of C-terminus of Hsc70-interacting protein (CHIP) E3 ubiquitin-ligase
impairs hepatic cytochrome P450 CYP2E1 degradation. Consequent CYP2E1 gain of …
impairs hepatic cytochrome P450 CYP2E1 degradation. Consequent CYP2E1 gain of …
[HTML][HTML] Regulation and function of nuclear IκBα in inflammation and cancer
I Vancurova, A Vancura - American journal of clinical and …, 2012 - ncbi.nlm.nih.gov
The nuclear translocation and accumulation of IκBα represents an important mechanism
regulating transcription of NFκB-dependent pro-inflammatory and anti-apoptotic genes. The …
regulating transcription of NFκB-dependent pro-inflammatory and anti-apoptotic genes. The …
Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and …
A Bravo-Cuellar, G Hernández-Flores… - Journal of biomedical …, 2013 - Springer
Abstract Background In Oncology, the resistance of the cancerous cells to chemotherapy
continues to be the principal limitation. The nuclear factor-kappa B (NF-κB) transcription …
continues to be the principal limitation. The nuclear factor-kappa B (NF-κB) transcription …
Curcumin suppresses oxidative stress via regulation of ROS/NF-κB signaling pathway to protect retinal vascular endothelial cell in diabetic retinopathy
J Huang, Q Yi, Y You, Y Chen, T Niu, Y Li… - Molecular & Cellular …, 2021 - Springer
Background The retinal vascular endothelial cells can be damaged by oxidative stress even
in the early stage of diabetic retinopathy (DR). This study aimed to investigate the protective …
in the early stage of diabetic retinopathy (DR). This study aimed to investigate the protective …
Analysis of TGFβ1 and IL-10 transcriptional regulation in CTCL cells by chromatin immunoprecipitation
TP Chang, M Kim, I Vancurova - Cytokine Bioassays: Methods and …, 2014 - Springer
The immunosuppressive cytokines transforming growth factor β1 (TGFβ1) and interleukin-10
(IL-10) regulate a variety of biological processes including differentiation, proliferation, tissue …
(IL-10) regulate a variety of biological processes including differentiation, proliferation, tissue …