The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

One of the most common chronic liver disorders, affecting mainly people in Western
countries, is nonalcoholic fatty liver disease (NAFLD). Unfortunately, its pathophysiological …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome. The underlying causes of the disease progression in NAFLD are unclear. Recent …

Given the unprecedented global pandemic of obesity, a better understanding of the etiology
of adiposity will be necessary to ensure effective management of obesity and related …

Nonalcoholic fatty liver disease (NAFLD) has emerged as a common public health problem
in recent decades. However, the underlying mechanisms leading to the development of …

The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway
that is activated to regulate protein synthesis and restore homeostatic equilibrium when the …

Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …

The endoplasmic reticulum (ER) governs the proper folding of polypeptides and proteins
through various chaperones and enzymes residing within the ER organelle. Perturbation in …

The association between inflammation and endoplasmic reticulum (ER) stress has been
observed in many diseases. However, if and how chronic inflammation regulates the …

Type 2 diabetes is often associated with obesity, dyslipidemia and cardiovascular anomalies
and is a major health problem approaching global epidemic proportions. Insulin resistance …