[HTML][HTML] Machine learning in clinical trials: A primer with applications to neurology

MI Miller, LC Shih, VB Kolachalama - Neurotherapeutics, 2023 - Elsevier
We reviewed foundational concepts in artificial intelligence (AI) and machine learning (ML)
and discussed ways in which these methodologies may be employed to enhance progress …

A review of physiological and behavioral monitoring with digital sensors for neuropsychiatric illnesses

E Reinertsen, GD Clifford - Physiological measurement, 2018 - iopscience.iop.org
Physiological, behavioral, and psychological changes associated with neuropsychiatric
illness are reflected in several related signals, including actigraphy, location, word …

Evaluation of smartphone‐based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial

F Lipsmeier, KI Taylor, T Kilchenmann… - Movement …, 2018 - Wiley Online Library
Background: Ubiquitous digital technologies such as smartphone sensors promise to
fundamentally change biomedical research and treatment monitoring in neurological …

Reliability and validity of the Roche PD Mobile Application for remote monitoring of early Parkinson's disease

F Lipsmeier, KI Taylor, RB Postuma… - Scientific reports, 2022 - nature.com
Digital health technologies enable remote and therefore frequent measurement of motor
signs, potentially providing reliable and valid estimates of motor sign severity and …

Computer vision quantification of whole-body Parkinsonian bradykinesia using a large multi-site population

G Morinan, Y Dushin, G Sarapata… - npj Parkinson's …, 2023 - nature.com
Parkinson's disease (PD) is a common neurological disorder, with bradykinesia being one of
its cardinal features. Objective quantification of bradykinesia using computer vision has the …

[HTML][HTML] A remote digital monitoring platform to assess cognitive and motor symptoms in Huntington disease: cross-sectional validation study

F Lipsmeier, C Simillion, A Bamdadian, R Tortelli… - Journal of Medical …, 2022 - jmir.org
Background Remote monitoring of Huntington disease (HD) signs and symptoms using
digital technologies may enhance early clinical diagnosis and tracking of disease …

Developing and assessing a new web-based tapping test for measuring distal movement in Parkinson's disease: a Distal Finger Tapping test

N Akram, H Li, A Ben-Joseph, C Budu, DA Gallagher… - Scientific reports, 2022 - nature.com
Disability in Parkinson's disease (PD) is measured by standardised scales including the
MDS-UPDRS, which are subject to high inter and intra-rater variability and fail to capture …

[HTML][HTML] Use of mobile apps for self-care in people with parkinson disease: systematic review

JH Lee, I Yeom, ML Chung, Y Kim, S Yoo… - JMIR mHealth and …, 2022 - mhealth.jmir.org
Background Self-care is essential for people with Parkinson disease (PD) to minimize their
disability and adapt to alterations in physical abilities due to this progressive …

Intelligent cyber-physical system for an efficient detection of Parkinson disease using fog computing

M Devarajan, L Ravi - Multimedia Tools and Applications, 2019 - Springer
Parkinson's disease is one of the notable neurodegenerative disorders caused by
insufficient production of dopamine which damages the motor skills and voice. Advancement …

Supervised classification of bradykinesia in Parkinson's disease from smartphone videos

S Williams, SD Relton, H Fang, J Alty, R Qahwaji… - Artificial Intelligence in …, 2020 - Elsevier
Background Slowness of movement, known as bradykinesia, is the core clinical sign of
Parkinson's and fundamental to its diagnosis. Clinicians commonly assess bradykinesia by …