Thousands of long noncoding RNAs (lncRNAs) are actively transcribed in mammalian
genomes. This class of RNAs has important regulatory functions in a broad range of cellular …

Simple Summary Long non-coding RNAs (lncRNAs) are generally defined as transcripts
longer than 200 nucleotides and not coding for proteins. This review provides an overview of …

RNA methylation is an important epigenetic modification. Recent studies on RNA
methylation mainly focus on the m6A modification of mRNA, but very little is known about the …

Human TRDMT1 is a transfer RNA (tRNA) methyltransferase for cytosine-5 methylation and
has been suggested to be involved in the regulation of numerous developmental processes …

Despite the development of novel therapeutic approaches and improved clinical
management, survival from metastatic disease remains poor. Indeed, metastasis accounts …

An emerging role of long non-coding RNAs (lncRNAs) in tumor progression has been
revealed in the last decade. Through interactions with nucleic acids and proteins, lncRNAs …

Deep whole genome and transcriptome sequencing have highlighted the importance of an
emerging class of non-coding RNA longer than 200 nucleotides (ie, long non-coding RNAs …

Abstract Model systems with defined genetic modifications are powerful tools for basic
research and translational disease modelling. Fortunately, generating state-of-the-art …

Nuclear organization has an important role in determining genome function; however, it is
not clear how spatiotemporal organization of the genome relates to functionality. To …

Aim: To study the biological function of NSUN2 in regulating gene expression and cell
proliferation. Materials & methods: The NSUN2 gene was knocked down in HEK293 cells …